Hydrogel-forming microneedles for rapid and efficient skin deposition of controlled release tip-implants

In this work, we introduce, for the first time, novel hybrid microneedle patches with implantable poly(lactic- co -glycolic acid) (PLGA) tips aligned hydrogel-forming bases (HFMB) using a dissolvable material. A model dye, Nile red, and an antifungal drug, amphotericin B, were loaded into PLGA in controlled manner by multiple castings. Three different types of pre-formed including conventional dissolving baseplates (MN0), HFMB needle heights 600 μm (MN6) 800 (MN8) investigated. Compared to baseplate (MN0)-based tipped design, addition improved vitro ex vivo insertion capacities patches, increased drug delivery efficiency up 80% speeded implantation process within 1 min. An adhesion test indicated that hydrogel used study was easier peel off from skin than baseplate. release studies demonstrated B loading lasts week. Antifungal tests inserted revealed their effects against Candida albicans . The MN8 did not dissolve, leaving no viscous residue but absorbed water disintegrated after immersion water. PLGA-tipped system will be ideal rapid sustained dermal fungal infections. This patch design is promising technology delivering drug-eluting microimplants while ensuring easy complete removal HFMB. It could have many potential applications intradermal delivery. • fabricated containing showed prolonged Delivery enhanced aligning base. took <1 Hydrogel-forming microneedles promoted efficient deposition.